RET-His, human recombinant

Catalogue #

P-124-100

Name

RET-His, human recombinant

Synonyms

Cadherin family member 12, Proto-oncogene c-Ret

Description

Protein contains only extracellular domain of the RET (aa 29-635)

Uniprot ID

P07949

Source

Human

MW

Approximately 68.6 kDa, a single non-glycosylated polypeptide chain containing 613 amino acids including C-terminal hexahistidine tag

Host

CHO-based cell line (expressed by QMCF Technology)

Purification

Purified by Ni-affinity chromatography and gel-filtration from serum-free CHO growth media

Concentration

0.23 mg/ml

Buffer

PBS pH 7.4

Endotoxine

Not tested

QC

Coomassie-stained SDS-PAGE

Shipping

Shipped on dry ice

Storage

Store at -70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles

Background

Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration

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