Figure 1. WB analysis of Huh-7 cell line expressing NS5B protein. Line 1. Huh-7 transfected with HCV replicon, Line 2. Huh-7 non-transfected cells.
Mouse mAb to HCV NS5B (clone 10D7)
HCV 1b NS5B
Recombinant Hepatitis C Virus subtype 1b non-structural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp)
Human, HCV subtype 1b NS5B, Epitope mapped to amino acids 92-105 (TPPHSARSKFGYGA)
Protein G purification
PBS pH 7.4, with 0.1% sodium azide
HCV subtype 1b monoclonal antibodies. For more information visit www.icosagen.com/products/?antibodies
This product is shipped in non-frozen liquid form in ambient conditions
Store at - 20 …-70 °C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles as product degradation may result.
Non-structural protein 5B (NS5B) represents the RNA-dependent RNA polymerase (RdRp) of Hepatitis C Virus, which is a small positive strand RNA virus in the family Flaviviridae. HCV is a major causative agent of acute and chronic hepatitis, hepatocellular carcinoma and liver cirrhosis. The single subunit RNA-dependent RNA polymerase is absolutely essential for the viral replication.
Nikonov A, Juronen E and Ustav M (2008)
Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase. J. Biol Chem. 283(35):24089-102.
This product is for research use only
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