GDNF, human recombinant


Datasheet as
Name GDNF, human recombinant
Synonyms Glial cell line-derived neurotrophic factor, Astrocyte-derived trophic factor (ATF)
Uniprot ID P39905
Source Human
MW Mature GDNF, Approximately 15 kDa, a single non-glycosylated polypeptide chain containing 134 amino acids
Host CHO-based cell line (expressed by QMCF Technology)
Purification Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media. Protein is sterile-filtrated through 0.22 µm filter
Concentration 0.96 mg/ml
Buffer PBS pH 7.4
Endotoxine Less than 1EU/mg of protein as determined by LAL method
QC Coomassie-stained SDS-PAGE analysis (Figure 1)
Background GDNF is an important member of the GDNF family of ligands. Four members of nurotrophic factors beloning to the GDNF family of ligands : glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). GDNF is important in the promotion of the survival of dopaminergic neurons. The recombinant form of this protein promotes the survival and differentiation of dopaminergic neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy.
Shipping Shipped on dry ice
Storage Store at -70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Related Products Monoclonal antibodies against human GDNF. For more information please visit:, human neural growth factors. For more information about protein production please visit:
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€249 / 10µg
€511 / 50µg
€908 / 100µg

Figure 1. Coomassie-stained SDS-PAGE analysis of human GDNF. Lane 1. 2 μg of GDNF (non-reduced); Lane 2. Protein size marker (Blue Protein Ladder Prestained, Naxo 8003). Lane 3. 2 μg of GDNF (reduced).

Figure 2.  EC50 concentration for final product and after 3 freeze-thaw cycles, determined by cRET-MAPK-nluc pathway in cell based assay.