Monoclonal antibody to Human Cardiac Troponin I


Datasheet as
Name Monoclonal antibody to Human Cardiac Troponin I, clone 5F8
Immunogen Recombinant human cardiac troponin complex
Immunogen Description Recombinant human cardiac troponin complex protein produced by CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line
Clonality Recombinant human monoclonal
Clone 5F8
Class Human IgG2-lambda
Reactivity human cardiac troponin I
Dissociation constant (KD) 1.60 x 10-10 M (Troponin complex binding from solution)
1 x 10-12 M (Troponin complex binding from streptavidin surface)
Application ELISA
Purification MabSelect affinity chromatography following gel filtration
Buffer 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 (SPTN)
Unit Size 100 µg
Related Products Monoclonal antibodies to human cardiac troponin I.  For more information
Shipping This product is shipped in non-frozen liquid form in ambient conditions
Storage Store at –20…-70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles
Background Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it, myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle (Wikipedia)
Limitations This product is for research use only.
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€323 / 100µg
€1292 / 500µg
€2098 / 1000µg