NGF, human recombinant

Catalogue #

P-104-100

Name

NGF, human recombinant

Synonyms

Beta-nerve growth factor, NGFB

Uniprot ID

P01138

Source

Human

MW

Mature NGF, Approximately 13.5 kDa, a single non-glycosylated polypeptide chain containing 120 amino acids

Host

CHO-based cell line (expressed by QMCF Technology)

Purification

Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media. Protein is sterile-filtrated through 0.22 µm filter

Concentration

0.27 mg/ml

Buffer

PBS+0,5 M imidazole

Endotoxine

Less than 1EU/mg of protein as determined by LAL method

QC

Coomassie-stained SDS-PAGE (Figure 1)

Shipping

Shipped on dry ice

Storage

Store at -70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles

Background

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (UniProt)

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