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Figure 1. Coomassie-stained SDS-PAGE analysis of human GDNF. Lane 1. 2 μg of GDNF (non-reduced); Lane 2. Protein size marker (Blue Protein Ladder Prestained, Naxo 8003). Lane 3. 2 μg of GDNF (reduced).
Figure 2. EC50 concentration for final product and after 3 freeze-thaw cycles, determined by cRET-MAPK-nluc pathway in cell based assay.
Catalogue #
P-103-100
Name
GDNF, human recombinant
Synonyms
Glial cell line-derived neurotrophic factor, Astrocyte-derived trophic factor (ATF)
Uniprot ID
P39905
Source
Human
MW
Mature GDNF, Approximately 15 kDa, a single non-glycosylated polypeptide chain containing 134 amino acids
Host
CHO-based cell line (expressed by QMCF Technology)
Purification
Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media. Protein is sterile-filtrated through 0.22 µm filter
Concentration
0.9 mg/ml
Buffer
PBS pH 7.4
Endotoxine
Less than 1EU/mg of protein as determined by LAL method
QC
Coomassie-stained SDS-PAGE analysis), cell based assay (cRET-MAPK-nluc pathway) showing functionality
Related Products
Monoclonal antibodies against human GDNF.
Shipping
Shipped on dry ice
Storage
Store at -70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Background
GDNF is an important member of the GDNF family of ligands. Four members of nurotrophic factors beloning to the GDNF family of ligands : glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). GDNF is important in the promotion of the survival of dopaminergic neurons. The recombinant form of this protein promotes the survival and differentiation of dopaminergic neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy.
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