Search from website

GDNF, human recombinant

 

Figure 1. Coomassie-stained SDS-PAGE analysis of human GDNF. Lane 1. 2 μg of GDNF (non-reduced); Lane 2. Protein size marker (Blue Protein Ladder Prestained, Naxo 8003). Lane 3. 2 μg of GDNF (reduced).

     

Figure 2.  EC50 concentration for final product and after 3 freeze-thaw cycles, determined by cRET-MAPK-nluc pathway in cell based assay.

Select volume:

Quantity:

Catalogue #

P-103-100

Name

GDNF, human recombinant

Synonyms

Glial cell line-derived neurotrophic factor, Astrocyte-derived trophic factor (ATF)

Uniprot ID

P39905

Source

Human

MW

Mature GDNF, Approximately 15 kDa, a single non-glycosylated polypeptide chain containing 134 amino acids

Host

CHO-based cell line (expressed by QMCF Technology)

Purification

Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media. Protein is sterile-filtrated through 0.22 µm filter

Concentration

0.9 mg/ml

Buffer

PBS pH 7.4

Endotoxine

Less than 1EU/mg of protein as determined by LAL method

QC

Coomassie-stained SDS-PAGE analysis), cell based assay (cRET-MAPK-nluc pathway) showing functionality

Related Products

Monoclonal antibodies against human GDNF.

Shipping

Shipped on dry ice

Storage

Store at -70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles

Background

GDNF is an important member of the GDNF family of ligands. Four members of nurotrophic factors beloning to the GDNF family of ligands : glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). GDNF is important in the promotion of the survival of dopaminergic neurons. The recombinant form of this protein promotes the survival and differentiation of dopaminergic neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy.

Custom price

Custom quantity - ask quotation

This product is for research use only

TECHNICAL ASSISTANCE

Please refer any technical questions to

technical.support@icosagen.com

Our locations

United States Office

77 Geary St. 5th Floor
San Francisco, CA 94108
+1 415 548 6625

European Office

Eerika tee 1
Õssu, Kambja vald
Tartu maakond 61713
Estonia
+372 737 7070
error:
Shopping Cart