BDNF, human recombinant

Catalogue #

P-105-100

Name

BDNF, human recombinant

Synonyms

Brain-derived neurotrophic factor, Abrineurin

Uniprot ID

P23560

Source

Human

MW

Mature BDNF, Approximately 13.5 kDa, a single non-glycosylated polypeptide chain containing 119 amino acids

Host

CHO-based cell line (expressed by QMCF Technology)

Purification

Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media. Protein is sterile-filtrated through 0.22 µm filter

Concentration

1 mg/ml

Buffer

10mM Na-atsetaat pH 5, 150 mM NaCl

Endotoxine

Less than 1EU/mg of protein as determined by LAL method

QC

Coomassie-stained SDS-PAGE analysis

Related Products

Monoclonal antibodies against human BDNF.

Shipping

Shipped on dry ice

Storage

Store at -70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles

Background

BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (UniProt)

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