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Icosagen developed anti-human BNDF antibody clone 3C11 played prominent role in Neuroscience and JBC publications.

In March, 2016 two research groups published their results in Neuroscience and JBC using Icosagen-developed anti-human BDNF antibody.

Anti-BDNF clone 3C11 made it possible for Chacón-Fernández et al. to discover that human and rat megakaryocytes express the BDNF. At the same time, Zunino and colleagues determined that the levels of mature BDNF protein were lower in the neocortex of En2-/- mice, as compared to WT, indicating pathogenic role of altered BDNF signalling in this mouse model of autism spectrum disorders.

References of the publications:  

Brain-derived neurotrophic factor signaling is altered in the forebrain of Engrailed-2 knockout mice. Zunino G, Messina A, Sgadò P, Baj G, Casarosa S, Bozzi Y. Neuroscience. March 14, 2016

Brain-derived Neurotrophic Factor in Megakaryocytes. Pedro Chacón-Fernández, Katharina Säuberli, Maria Colzani*, Thomas Moreau, CedricGhevaert and Yves-Alain Barde. JBC. March 22, 2016

“The lack of suitable, i.e. sensitive and specific reagents allowing the reliable detection of BDNF after Western blotting has been a real problem in the field. This has now been resolved following the development by Icosagen (Tartu, Estonia)  of a remarkably useful mouse monoclonal antibody designated 3C11.  It recognises mammalian BDNF and pro-BDNF on Western blot with high selectivity and sensitivity. For illustration, see:  Brain-derived Neurotrophic Factor in Megakaryocytes. Chacón-Fernández P, Säuberli K, Colzani M, Moreau T, Ghevaert C, Barde YA. J Biol Chem. 2016 Mar 22. pii: jbc.M116.720029.”

Yves-Alain Barde, March 2016     

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