News
April 19, 2022

Diagnostic antibodies against IL-6 with high sensitivity and wide dynamic range!

Icosagen has developed high sensitivity monoclonal antibodies against IL-6 with wide dynamic range. We have 6 different antibody clones available, which experimentally show no cross-reactivity with IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-8, IFNγ, TNFα cytokines.
In addition to antibodies, recombinant human IL-6 antigen is in stock.


IL-6 is a well-known marker for detecting bacterial and viral infections, tissue damage, Covid-19 severity and monitoring inflammation. IL-6 levels in human blood are known to be low, while in the case of infection can increase thousand-fold in a short time period, thus creating a need for dynamic antibodies.    

Superior diagnostic reagents developed by Icosagen with pharma-grade recombinant technologies!




Figure 1. Lower detection limit on 11.3 pg/ml and 14.3 pg/ml can be reached with these antibody pairs. We tested different antibody pairs with CLIA and see best results when using clone 12C1 and 14E2 for capture and 2G12 for detection (see figures above).


Clone KD  (M)Kon (1/S) Kdis (1/S)
2A103,96E-094,55E+051,80E-03
2G124,83E-092,90E+051,40E-03
11C51,84E-095,94E+051,09E-03
11D81,82E-09  5,22E+05
9,52E-04
12C12,11E-091,38E+052,9E-04
14E22,08E-093,36E+057,01E-04
All antibodies above are currently available in the catalogue.
Get in touch with us for more information and orders!
sales@icosagen.com


‹ Back to news