News
June 10, 2014

QMCF Technology based CHO/Furin expression cell line is available

Icosagen has developed a novel QMCF/CHO based stable cell line (CHOEBNALT85-furin) co-expressing furin, one of the major proprotein convertases.

Large number of proteins are processed by different cellular proteases in order to convert proproteins into their active form. In CHO cells furin expression is relatively low and insufficient for processing of expressed proteins, therefore this new cell line bridges the gap to generate biologically active proteins. 

Comparison expression of human GDNF using CHOEBNALT85 and CHOEBNALT85-furin cell lines resulted with processed protein in case if furin expressing cell line was used.













The cell line is used in service project to produce proteins and is available for licensing.


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