Molecular Biology Products

Among the products we provide are monoclonal and polyclonal antibodies, products based on E2 Tag tagging technology etc.
Molecular Biology Products

Publications HIV-1/SIV-1 MAbs


  1. Ovod V., A. Lagerstedt, A. Ranki, F.O. Gombert, R. Spohn, M. Tahtinen, G. Jung, and K.J. Krohn. (1992) Immunological variation and immunohistochemical localization of HIV-1 Nef demonstrated with monoclonal antibodies. AIDS, 6:25-34. PubMed ID: 1371924
    Used antibodies: 3F2  (01-001), 3D12  (01-002), 2F2  (01-003),  3E6  (01-004), 2A3  (01-005), 3A2  (01-006), 2H12   (01-007)
  2. Saito Y., L. Sharer, L. Epstein, and et. al. (1994) Overexpression of Nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology, 44:474-481. PubMed ID: 8145918 
    Used antibodies: HIV-1 nef 3F2  (01-001), 3D12  (01-002), 2F2  (01-003), 3E6  (01-004), 3A2  (01-006), 2H12   (01-007)
  3. Ranki A., A. Lagerstedt, V. Ovod, E. Aavik, and K. Krohn (1994) Expression kinetics and subcellular localization of HIV-1 regulatory proteins Nef and Tat in established lymphoid cell lines. Arch. Virol., 139:365-378. PubMed ID: 7832642
    Used antibodies: HIV-1 nef 3F2  (01-001), 3D12  (01-002), 2F2  (01-003), 3E6  (01-004), 2H12  (01-007); Rev 10  (03-002); Tat 1.  (02-001) 
  4. Ranki A., M. Nyberg, V. Ovod, M. Haltia, I. Elovaara, R. Raininko, H. Haapasalo, and K. Krohn. (1995) Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia. AIDS, 9:1001-1008. PubMed ID: 8527071 
    Used antibodies: HIV-1 nef 3F2  (01-001), 3D12  (01-002), 2F2  (01-003), 3E6  (01-004), 3A2  (01-006), 2H12  (01-007), JR6  (01-009); Rev 10  (03-002); Tat 1.  (02-001)
  5. Campioni, D., Corallini, A., Zauli, G., Possati, L., Altavilla, G. and Barbanti-Brodano, G. (1995) HIV type I extracellular Tat protein stimulates growth and protects cells of BK virus/tat transgenic mice from apoptosis. AIDS Res Hum Retroviruses 11, 1039-1048. PubMed ID: 8554901 Used antibodies: Tat 15 (02-003)
    7. Fiala, A.M., R.H. Rhodes, P. Shapshak, I. Nagano, O. Martinez-Maza, A. Diagne, G. Baldwin, and M. Graves. (1996) Regulation of HIV-1 infection in astrocytes: Expression of NEF, TNF-alpha and IL-6 is enhanced in coculture of astrocytes with macrophages. J.Neurovirology, 2, No. 3 158-166. PubMed ID: 8799208
    Used antibodies: 3E6 (01-004), 3A2 (01-006)
  7. Collings, A., Pitkanen, J., Strengell, M., Tahtinen, M., Lagerstedt, A., Hakkarainen, K., Ovod, V., Sutter, G., Ustav, M., Ustav, E., Mannik, A., Ranki, A., Peterson, P., Krohn, K. (1999) Humoral and cellular immune responses to HIV-1 nef in mice DNA-immunised with non-replicating or self-replicating expression vectors. Vaccine. 18(5-6):460-7. PubMed ID: 10519935
    Used antibodies: a mixture of monoclonal antibodies to HIV-1 Nef 3F2  (01-001), 3D12  (01-002), 2F2  (01-003), 3E6  (01-004), 2A3  (01-005), 3A2  (01-006), 2H12  (01-007)
  8. Koedel, U., Kohleisen B, Sporer B, Lahrtz F, Ovod V, Fontana A, Erfle V, Pfister HW. HIV type 1 Nef protein is a viral factor for leukocyte recruitment into the central nervous system. (1999) J Immunol. 1;163(3):1237-45. PubMed ID: 10415019
    Used antibodies: 3E6  (01-004), 2H12  (01-007)
  9. Rohr O, C Schwartz, C Hery, D Aunis, M Tardieu and E Schaeffer. (2000) The nuclear receptor COUP-TF interacts with HIV-1 Tat and stimulates viral replication in human microglial cells. Journal of Biological Chemistry. 28;275(4): 2654-60. PubMed ID: 10644726
    Used antibodies: Tat 15 (02-003)
  10. Kohleisen B., Hutzler P, Shumay E, Ovod V, Erfle V. (2001)HIV-1 Nef co-localizes with the astrocyte-specific cytoskeleton protein GFAP in persistently nef-expressing human astrocytes. J Neurovirol. 7(1):52-5. PubMed ID: 11519482
    Used antibodies: HIV-1 nef     2A3  (01-005), 2H12  (01-007)
  11. Kjerrström, A., J. Hinkula, G.Engström, V.Ovod, K.Krohn, R.Benthin and B.Wahren. (2001) Interactions of Single and Combined Human Immunodeficiency Virus Type 1 (HIV-1) DNA Vaccines. Virology 284(1): 46-61. PubMed ID: 11352667 
    Used antibodies: HIV-1 nef 3F2  (01-001), 3D12  (01-002), 2F2  (01-003), 3E6  (01-004),2A3 (01-005), 3A2  (01-006), 2H12  (01-007); HIV-1 Rev 10.  (03-002); HIV-1 Tat 1.  (02-001)
  12. Reid W., Sadowska M., Denaro, F. Rao S., Foulke J., Hayes N., Jones 0., Davis H., Sill A., O'Driscoll P., Huso, D., Fouts T., Lewis, G., Kames-Lowis R., Wei C., Ray P, Gallo, R., Reits, M., and Bryant J. (2001) An HIV -1 Transgenic Rat that Develops HIV -1 related Pathology and Immunological Dysfunction. Proceedings of the National Academy of Science 98 (16): 9271-9276. PubMed ID: 11481487
    Used antibodies: HIV-1 nef 3F2  (01-001); HIV-1 Tat 7.  (02-002)
  13. Maksiutov AZ, Bachinskii AG, and Bazhan SI. (2002) [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459. Article in Russian. PubMed ID: 12068630 
    Used antibodies: HIV-1 nef 3F2  (01-001), 3D12  (01-002), 2F2  (01-003), 3E6  (01-004); HIV-1 Rev 10.  (03-002)
  14. Henderson WW, Ruhl R, Lewis P, Bentley M, Nelson JA and Moses AV. (2004) Human immunodeficiency virus (HIV) type 1 Vpu induces the expression of CD40 in endothelial cells and regulates HIV-induced adhesion of B-lymphoma cells. J Virol 78: 4408-4420. PubMed ID: 15078922
    Used antibodies: HIV-1 Tat 1. (02-001)
  15. Arp J, Rieder MJ, Urquhart B, Freeman D, Tucker MJ, Krizova A, Lehmann D, Dekaban GA (2005). Hypersensitivity of HIV-1 infected cells to reactive sulfonamide metabolites correlated to expression of the HIV-1 viral protein tat. J. Pharmcol Exp Ther 314:1218-25. PubMed ID: 15933158
    Used antibodies: HIV-1 Tat 15 (02-003)
  16. Lehmann M.H., Walter S., Ylisastigui L., Striebel F., Ovod V., Geyer M., Gluckman J.C., Erfle V. (2006) Extracellular HIV-1 Nef increases migration of monocytes. Exp Cell Res. 1;312(18):3659-68. PubMed ID: 16978607
    Used antibodies: HIV-1 nef 3D12 (01-002), 2H12 (01-007)
  17. Blazevic, V., Männik, A., Malm, M., Sikut, R., Valtavaara, M., Toots, U., Ustav, M., and K. Krohn. (2006) Induction of Human Immunodeficiency Virus Type-1-Specific Immunity with a Novel Gene Transport Unit (GTU)-MultiHIV DNA Vaccine. AIDS Research and Human Retroviruses, 7: 667-677. PubMed ID: 16831091 
    Used antibodies:HIV-1 nef 3F2  (01-001); HIV-1 p24 5. (05-001) 
  18. Lehmann M.H., Masanetz S., Kramer S., Erfle V. (2006) HIV-1 Nef upregulates CCL2/MCP-1 expression in astrocytes in a myristoylation- and calmodulindependent manner J Cell Sci 119: 4520-30 PubMed ID: 17046994 
    Used antibodies: HIV-1 nef 3E6 (01-004) 
  19. Malm M, Sikut R, Krohn K, Blazevic V.(2007) GTU-MultiHIV DNA vaccine results in protection in a novel P815 tumor challenge model. Vaccine 30;25(17):3293-301. PubMed ID: 17289222 
    Used antibodies: HIV-1 nef 3F2  (01-001); HIV-1 p24 5. (05-001) 
  20. Abbott KL, Archambault J, Xiao H, Nguyen BD, Roeder RG, Greenblatt J, Omichinski JG, Legault P. (2005) Interactions of the HIV-1 Tat and RAP74 Proteins with the RNA Polymerase II CTD Phosphatase FCP1. Biochemistry 44, 2716-2731. PubMed ID: 15723517  
    Used antibodies: HIV-1 Tat 15. (02-003) 
  21. Karasev AV, Foulkeb S, Wellensa C, Richa A, Shona KJ, Zwierzynskia I, Honeb D, Koprowskia H, Reitz M (2005) Plant based HIV-1 vaccine candidate: Tat protein produced in spinach. Vaccine 23: 1875–1880. PubMed ID: 15734059 
    Used antibodies: Tat 15. (02-003) 
  22. Rolland M, Jensen MA, Nickle DC,Yan J, Learn GH,1 Heath L, Weiner D, Mullins JI. (2007) Reconstruction and Function of Ancestral Center-of-Tree Human Immunodeficiency Virus Type 1 Proteins. Journal of Virology, Vol. 81, No. 16: 8507–8514. PubMed ID: 17537854
    Used antibodies: Tat 15. (02-003)

SIV-1 nef references:
  1. Khan IH, Sawai ET, Antonio E, Weber CJ, Mandell CP, Montbriand P, Luciw PA. (1998) Role of the SH3-Ligand Domain of Simian Immunodeficiency Virus Nef in Interaction with Nef-Associated Kinase and Simian AIDS in Rhesus Macaques. J. Virol. 72: 5820-30. PubMed ID: 9621042
    Used antibodies: SIV-1 nef     17. (04-001)
  2. Piguet V, Chen Y-L, Mangasarian A, Foti M, Carpentier J-L, Trono D. (1998) Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the µ chain of adaptor complexes. EMBO, 17 (9): 2472-81. PMID: 9564030
    Used antibodies: SIV-1 nef 17.  (04-001)
  3. Mandell CP, Reyes RA, Cho K, Sawai ET, Fang AL, Schmidt KA, Luciw PA.(1999) SIV/HIV Nef recombinant virus (SHIVnef) produces simian AIDS in rhesus macaques. Virology. 20;265(2):235-51. PubMed ID: 10600596
    Used antibodies: SIV-1 nef 17.  (04-001) 
  4. Sawai ET, Hamza MS, Ye M, Shaw KE, Luciw PA. (2000) Pathogenic Conversion of Live Attenuated Simian Immunodeficiency Virus Vaccines Is Associated with Expression of Truncated Nef. Journal of Virology, 74:4, 2038-2045. PubMed ID: 10644378 
    Used antibodies: SIV-1 nef 17. (04-001)
  5. Guillemin G, Croitoru J, Le-Grand R, Franck-Duchenne M, Dormont D, Boussin F D. (2000) Simian immunodeficiency virus mac251 infection of astrocytes. J of Neurovirology 6(3): 173-186. PubMed ID: 10878708 
    Used antibodies: SIV-1 nef 17. (04-001)
  6. Chan KS, Verardi PH, Legrand FA, Yilma TD. (2005) Nef from pathogenic simian immunodeficiency virus is a negative factor for vaccinia virus. PNAS 102(24): 8734-9. PMID: 15930136
    Used antibodies: SIV-1 nef 17.  (04-001)